TRP Channel Antagonist

TRP Channel Antagonists (77):

Cat. No.	Product Name	Effect	Purity

HY-P1175B

L-R4W2 acetate	Antagonist	98.13%
L-R4W2 acetate is a potent antagonist of vanilloid receptor 1 (VR1, TRPV1), with an IC₅₀ of 0.1 μM. L-R4W2 acetate may act as a potent analgesic.

HY-15640

Capsazepine	Antagonist	99.05%
Capsazepine is a synthetic analogue of the sensory neurone excitotoxin, and an antagonist of TRPV1 receptor with an IC₅₀ of 562 nM.

HY-101736

AMG9810	Antagonist	99.48%
AMG9810 is a selective and competitive vanilloid receptor 1 (TRPV1) antagonist with IC₅₀ values of 24.5 and 85.6 nM for human and rat TRPV1, repectively.

HY-10634

AMG 517	Antagonist	99.24%
AMG 517 is a potent and selective vanilloid receptor-1 (TRPV1) antagonist with an IC₅₀ of 0.5 nM.

HY-108463

A-967079	Antagonist	99.30%
A-967079 is a selective TRPA1 receptor antagonist with IC₅₀s of 67 nM and 289 nM at human and rat TRPA1 receptors, respectively, and has good penetration into the blood-brain barrier.

HY-111925

BI-749327	Antagonist	99.91%
BI-749327 is a potent, high selectivity and orally bioavailable TRPC6 antagonist, with IC₅₀s of 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6, respectively. BI-749327 is 85-fold more selective for mouse TRPC6 than TRPC3 and 42-fold versus TRPC7.

HY-10633

SB-705498	Antagonist	99.72%
SB-705498 is a potent, selective and orally bioavailable transient receptor potential vanilloid 1 (TRPV1) receptor antagonist with a pIC₅₀ of 7.1.

HY-19960

BCTC	Antagonist	99.66%
BCTC is an orally active current inhibitor of vanilloid receptor type 1 (VR1). BCTC is a transient receptor potential cation channel subfamily M member 8 (TRPM8) and transient receptor potential vanilloid 1 (TRPV1) antagonist. BCTC is an insulin sensitizer and secretor. BCTC has anticancer and analgesic effects.

HY-112302

HC-070	Antagonist	99.74%
HC-070 is an antagonist of TRPC4/TRPC5, with IC₅₀s of 9.3 nM and 46 nM for hTRPC5 and hTRPC4 in cells, respectively.

HY-16935

Mavatrep	Antagonist	99.67%
Mavatrep (JNJ-39439335) is an orally active, selective and potent TRPV1 antagonist with high affinity for hTRPV1 channels (K_i=6.5 nM). Mavatrep antagonizes capsaicin-induced Ca²⁺ influx with an IC₅₀ value of 4.6 nM. Mavatrep can be used in some studies of neuropathic pain.

HY-N1378

(E)-Cardamonin	Antagonist	99.84%
(E)-Cardamonin ((E)-Cardamomin) is a novel antagonist of hTRPA1 cation channel with an IC₅₀ of 454 nM.

HY-12777

Asivatrep	Antagonist
Asivatrep (PAC-14028) is a potent and selective transient receptor potential vanilloid type I (TRPV1) antagonist.

HY-112430

TRPM8 antagonist 2	Antagonist	98.09%
TRPM8 antagonist 2 is a potent and selective TRPM8 antagonist, with an IC₅₀ of 0.2 nM, used in the research of neuropathic pain syndromes.

HY-112703

AMG 333	Antagonist	99.82%
AMG 333 is an orally active and highly selective TRPM8 antagonist with an IC₅₀ of 13 nM.

HY-109087

Elismetrep	Antagonist	99.42%
Elismetrep (MT-8554) is a TRPM8 antagonist. Elismetrep reduces the frequency of vasomotor symptoms. Elismetrep can be used for study of pain.

HY-B0985

Phenazopyridine hydrochloride	Antagonist	99.55%
Phenazopyridine hydrochlorideis a competitive SARM1 inhibitor, with IC₅₀ 145 μM. Phenazopyridine hydrochlorideis a TRPM8 antagonist. Phenazopyridine hydrochloride has a local anesthetic/analgesic effect. Phenazopyridine hydrochlorideis used to relieve painful symptoms of conditions such as cystitis and urethritis. Phenazopyridine hydrochloridecan promote neuronal differentiation and can also be used in the study of traumatic brain injury, peripheral neuropathy and neurodegenerative diseases.

HY-104059

AMG2850	Antagonist	99.89%
AMG2850 is a potent, orally bioavailable and selective transient receptor potential melastatin 8 (TRPM8) antagonist.

HY-108329

AM-0902	Antagonist	99.73%
AM-0902 is a potent, selective transient receptor potential A1 (TRPA1) antagonist with IC₅₀s of 71 and 131 nM for rTRPA1 and hTRPA1, respectively.

HY-132813

Evifacotrep	Antagonist	99.65%
Evifacotrep, a short transient receptor potential channel 5 and 4 (TRPC5/TRPC4) antagonist (WO2020061162, compound 100), can be used for the research of neurological diseases. Evifacotrep targets to TRPC5/TRPC4 with IC₅₀s ≤50 nM.

HY-110270

RN-9893	Antagonist	99.91%
RN-9893 is a potent and selective TRPV4 receptor antagonist with IC₅₀ values of 320, 420 and 660 nM for mouse, human and rat channels, respectively.

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